I have some nice guitars, but none are one-of-a-kind or have special sentimental value that makes them irreplaceable. I am OK with my sons' friends playing my nicer guitars without my presence as long as they don't take them out of the guitar room. I will let anybody play the guitars that are in the living room on stands.
I would lend my best guitar to my best friend for a limited time, but it is moot because he doesn't play guitar

And Rick, remember the cold beer-can compress for after surgery!